Analytical Data
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Gene name
PARK7
- Application
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Alternative Names
DJ1; Autosomal Recessive,Early Onset
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99497
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Expression Region
Met1~Asp189
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PARK7, also known as DJ-1, is a multifaceted protein that plays a crucial role in cellular protection against oxidative stress and mitochondrial dysfunction, making it particularly relevant in the context of neurodegenerative diseases such as Parkinson’s disease. Mutations in the PARK7 gene are linked to early-onset familial Parkinson's, highlighting its significance in neuronal health and survival. Research into PARK7 encompasses its structure, function, and mechanisms of action, with a focus on its role as a redox-sensitive chaperone, regulating protein homeostasis and preventing cell death. Moreover, PARK7's involvement in various cellular processes, including the regulation of gene expression and the maintenance of cellular energy levels, underscores its importance in overall cellular physiology. Understanding PARK7 and developing recombinant forms of the protein can provide insights into therapeutic avenues for neurodegenerative disorders and may lead to novel biomarker identification for early diagnosis and progression monitoring. These studies are not only crucial for elucidating the molecular underpinnings of disease but also for exploring potential interventions that can enhance cellular resilience, ultimately contributing to the development of targeted therapies for patients affected by dopaminergic neuron degeneration.
