Analytical Data
-
Gene name
NLGN4X
- Application
-
Alternative Names
ASPGX2; AUTSX2; HLNX; HNLX; NLGN; NLGN4; Neuroligin 4
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8N0W4
-
Expression Region
Gln42~Asn320
-
Molecular Weight
32kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NLGN4X, a member of the neuroligin family, plays a significant role in synapse formation and function within the central nervous system. It is located on the X chromosome, and its mutations have been linked to neurodevelopmental disorders, including autism spectrum disorder (ASD). Research has shown that NLGN4X interacts with neurexins and other synaptic proteins, which are crucial for maintaining synaptic stability and plasticity. The study of NLGN4X recombinant proteins has gained traction as it provides insights into the molecular mechanisms underlying synaptic transmission and the pathogenic effects of its variants. By expressing and characterizing NLGN4X recombinant proteins, researchers aim to elucidate how specific mutations affect protein structure and function, leading to synaptic dysfunction associated with neurological disorders. This research not only enhances our understanding of synapse biology but also has potential implications in developing therapeutic strategies for treating disorders linked to NLGN4X dysregulation. Overall, the study of NLGN4X recombinant proteins is critical for advancing our knowledge of synaptic mechanisms and their roles in neurodevelopmental conditions.
