Analytical Data
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基因名
SNAI1
- Application
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别名
SLUGH2; SNA; SNAH; Snail 1 Zinc Finger Protein
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95863
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表达区间
Met1~Arg264
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNAI1, a pivotal transcription factor, plays a crucial role in epithelial-mesenchymal transition (EMT), a process essential for embryonic development, tissue repair, and cancer metastasis. Research has shown that SNAI1 mediates the downregulation of epithelial markers and the upregulation of mesenchymal markers, facilitating cell migration and invasion. Its involvement in various pathological conditions, particularly in the context of cancer, has garnered significant attention in the scientific community. Studies indicate that aberrant SNAI1 expression contributes not only to tumor progression but also to drug resistance, highlighting its potential as a therapeutic target. The exploration of SNAI1-recombinant proteins focuses on understanding its mechanistic role in EMT and related pathways. By producing and characterizing these recombinant proteins, researchers aim to elucidate SNAI1's interaction with other cellular components, assess its functional implications in cell behavior, and evaluate its potential as a biomarker for cancer prognosis. Advances in recombinant protein technology allow for the generation of active SNAI1 proteins, facilitating in vitro and in vivo studies that further unravel the complexities of its role in developmental biology and disease. This research is essential for developing innovative therapeutic strategies aimed at modulating SNAI1 activity in various diseases, particularly in enhancing the efficacy of existing cancer treatments. Overall, the characterization of SNAI1-recombinant proteins is pivotal for both basic research and clinical applications, offering insights into the fundamental processes that govern cellular dynamics and disease progression.












