Analytical Data
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基因名
EZH1
- Application
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别名
KMT6B; ENX-2; Histone-lysine N-methyltransferase EZH1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92800
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表达区间
Pro559~Leu747
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分子量
25kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EZH1, a member of the Polycomb Repressive Complex 2 (PRC2), plays a crucial role in gene regulation through its histone methyltransferase activity, specifically in tri-methylating lysine 27 of histone H3 (H3K27me3). This specific modification is essential for maintaining gene repression during developmental processes and cellular differentiation. Dysregulation of EZH1 has been implicated in various cancers, suggesting its pivotal role in tumorigenesis and the potential as a therapeutic target. In recent studies, researchers have focused on the structural characteristics and enzymatic mechanisms of EZH1, exploring how its activity is modulated by post-translational modifications and interactions with other proteins. Understanding the functional dynamics of EZH1 in both normal development and disease contexts can provide insights into its role as a cancer marker and facilitator of oncogenic pathways. Consequently, the generation of recombinant EZH1 protein has become a focus for researchers aiming to explore its biochemical properties and to develop novel inhibitor drugs that target its enzymatic function. This research not only contributes to the basic understanding of chromatin biology but also offers prospects for innovative cancer therapies targeting epigenetic regulators like EZH1.
