Analytical Data
-
基因名
FBXL3
- Application
-
别名
FBL3; FBL3A; FBXL3A; F-box/LRR-repeat protein 3A
-
种属
Mouse
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q8C4V4
-
表达区间
Met1~Tyr292
-
分子量
37kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FBXL3, or F-box and leucine-rich repeat protein 3, is a member of the F-box protein family involved in the ubiquitin-proteasome system, which regulates proteolysis and controls various cellular processes. It plays a crucial role in the circadian rhythm by targeting specific proteins for degradation, thereby influencing the stability of key circadian clock components. Research has shown that FBXL3 interacts with CRY proteins, which are vital for maintaining circadian oscillations. Dysregulation of FBXL3 has been implicated in various disorders, including sleep disorders and metabolic syndrome. Studies focusing on the recombinant expression of FBXL3 protein provide insights into its structure and functional mechanisms. By expressing FBXL3 in heterologous systems, researchers aim to elucidate its protein-protein interactions, post-translational modifications, and the regulatory pathways it influences. Understanding the role of FBXL3 in circadian biology could offer new therapeutic strategies for managing circadian-related disorders. Furthermore, the production of recombinant FBXL3 serves as a valuable tool for biochemical assays and potential drug development, making it an important subject of ongoing research in molecular biology and pharmacology.
