Analytical Data
-
Gene name
Integrin alpha V beta 6
-
简介
Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 6 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 6 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha V beta 6 Protein, Mouse (HEK293, His), has molecular weight of 90-140 kDa.
- Application
-
Alternative Names
ITGAV&ITGB6; Integrin alpha V beta 6
-
Species
Mouse
-
Source
HEK293
-
Tag
C-8*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P43406 (F31-V988)&Q9Z0T9
-
Expression Region
P43406 (F31-V988)&Q9Z0T9 (G22-N706)
-
Molecular Weight
90-140 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Integrin alpha V beta 6 is a significant member of the integrin family, which plays a crucial role in cell adhesion, migration, and signaling. This integrin is predominantly expressed in epithelial cells and is involved in various physiological processes, including wound healing, immune response, and tissue remodeling. Dysregulation of alpha V beta 6 has been implicated in several pathological conditions, such as fibrosis, cancer progression, and metastasis, making it a target of interest for therapeutic interventions. Research on recombinant alpha V beta 6 proteins focuses on understanding its structure, function, and interactions with extracellular matrix components. Additionally, studies have shown that this integrin can influence cellular behavior by modulating signaling pathways linked to growth and differentiation. As such, generating recombinant forms of integrin alpha V beta 6 is essential for elucidating its mechanism of action, exploring its role in disease, and developing potential strategies for targeted therapies or diagnostic tools. Recent advancements in recombinant protein technology enable the production of functional alpha V beta 6 proteins, facilitating biochemical assays and structural studies. Given its pivotal role in cell biology and pathology, ongoing research aims to further characterize integrin alpha V beta 6, contributing to our understanding of its biological significance and potential as a therapeutic target.
