Recombinant Human FLCN Protein，His & SUMO

FLCN (Folliculin) is a tumor suppressor protein encoded by the FLCN gene, which has been linked to the development of Birt-Hogg-Dubé syndrome (BHDS), a genetic disorder characterized by skin tumors, lung cysts, and an increased risk of renal cancer. Recent research has highlighted the critical role of FLCN in cellular processes such as energy metabolism, cell proliferation, and DNA damage response. The protein is part of the mTOR signaling pathway, which is essential for cellular growth and homeostasis. Studies have shown that mutations or loss of FLCN function can lead to dysregulation of these pathways, contributing to tumorigenesis. To better understand FLCN's biological functions and mechanisms of action, researchers have focused on the expression and purification of recombinant FLCN protein. This enables the exploration of its structural properties, interactions with other molecular partners, and regulatory roles within the cell. By studying FLCN in a controlled environment, scientists aim to uncover the molecular basis of BHDS and other related disorders, providing insights that could lead to targeted therapies and improved clinical outcomes. The elucidation of FLCN's function is crucial not just for understanding kidney cancer and BHDS, but also for broader applications in cancer biology and treatment strategies.