Analytical Data
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基因名
RAMP2
- Application
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别名
Calcitonin-receptor-like receptor activity-modifying protein 2; Receptor(G Protein-Coupled)Activity Modifying Protein 2; Receptor(Calcitonin)Activity Modifying Protein 2
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60895
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表达区间
Gln43~Val145
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分子量
43kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAMP2 (Receptor Activity-Modifying Protein 2) is a member of the RAMP family, which plays a crucial role in modulating the activity of Class B G-protein-coupled receptors (GPCRs). These receptors are integral to numerous physiological processes, including hormone regulation, neurotransmission, and cardiovascular functions. The expression and function of RAMP2 have been particularly linked to the calcitonin gene-related peptide (CGRP) receptor, which is associated with pain modulation and migraine pathophysiology. Research into RAMP2 recombinant proteins has gained traction due to their potential therapeutic implications. Understanding RAMP2's structure-function relationships can provide insights into its role in receptor signaling and may pave the way for the development of targeted therapies for conditions like migraine and other neurovascular disorders. Recent advancements in molecular biology techniques enable the production of recombinant RAMP2 proteins, facilitating detailed studies of their biochemical properties, interactions with GPCRs, and influence on receptor signaling pathways. By elucidating these mechanisms, researchers aim to harness RAMP2's functionality for drug development and the refinement of therapeutic strategies in mitigating pain and improving patient outcomes.
