Analytical Data
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Gene name
RAMP2
- Application
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Alternative Names
Calcitonin-receptor-like receptor activity-modifying protein 2; Receptor(G Protein-Coupled)Activity Modifying Protein 2; Receptor(Calcitonin)Activity Modifying Protein 2
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60895
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Expression Region
Gln43~Val145
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Molecular Weight
43kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RAMP2 (Receptor Activity-Modifying Protein 2) is a member of the RAMP family, which plays a crucial role in modulating the activity of Class B G-protein-coupled receptors (GPCRs). These receptors are integral to numerous physiological processes, including hormone regulation, neurotransmission, and cardiovascular functions. The expression and function of RAMP2 have been particularly linked to the calcitonin gene-related peptide (CGRP) receptor, which is associated with pain modulation and migraine pathophysiology. Research into RAMP2 recombinant proteins has gained traction due to their potential therapeutic implications. Understanding RAMP2's structure-function relationships can provide insights into its role in receptor signaling and may pave the way for the development of targeted therapies for conditions like migraine and other neurovascular disorders. Recent advancements in molecular biology techniques enable the production of recombinant RAMP2 proteins, facilitating detailed studies of their biochemical properties, interactions with GPCRs, and influence on receptor signaling pathways. By elucidating these mechanisms, researchers aim to harness RAMP2's functionality for drug development and the refinement of therapeutic strategies in mitigating pain and improving patient outcomes.
