Analytical Data
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基因名
RIMS2
- Application
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别名
OBOE; RAB3IP3; RIM2; Rab-3-interacting molecule 2
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9EQZ7
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表达区间
Val1346~Ser1530
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分子量
26kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RIMS2 (Regulating Synaptic Membrane Exocytosis 2) is a crucial protein involved in synaptic transmission and neurotransmitter release in the nervous system. Research has shown that RIMS2 plays a significant role in the regulation of synaptic vesicle exocytosis, particularly in the release of neurotransmitters at presynaptic terminals. The protein is associated with calcium channels and interacts with various synaptic proteins, which facilitates the docking and priming of synaptic vesicles at the active zone. The study of RIMS2 is particularly relevant in understanding neurological disorders, as anomalies in its function may contribute to conditions such as autism spectrum disorders, epilepsy, and other synaptic transmission-related diseases. By examining the structure and function of RIMS2 through recombinant protein studies, researchers aim to elucidate its precise mechanisms in synaptic dynamics and identify potential therapeutic targets for treating synaptic dysfunction. The advancements in techniques such as cryo-electron microscopy and protein interaction assays have enabled deeper insights into the molecular pathways involving RIMS2, highlighting its importance in neuronal communication and overall brain function.
