Analytical Data
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Gene name
RIMS2
- Application
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Alternative Names
OBOE; RAB3IP3; RIM2; Rab-3-interacting molecule 2
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9EQZ7
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Expression Region
Val1346~Ser1530
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RIMS2 (Regulating Synaptic Membrane Exocytosis 2) is a crucial protein involved in synaptic transmission and neurotransmitter release in the nervous system. Research has shown that RIMS2 plays a significant role in the regulation of synaptic vesicle exocytosis, particularly in the release of neurotransmitters at presynaptic terminals. The protein is associated with calcium channels and interacts with various synaptic proteins, which facilitates the docking and priming of synaptic vesicles at the active zone. The study of RIMS2 is particularly relevant in understanding neurological disorders, as anomalies in its function may contribute to conditions such as autism spectrum disorders, epilepsy, and other synaptic transmission-related diseases. By examining the structure and function of RIMS2 through recombinant protein studies, researchers aim to elucidate its precise mechanisms in synaptic dynamics and identify potential therapeutic targets for treating synaptic dysfunction. The advancements in techniques such as cryo-electron microscopy and protein interaction assays have enabled deeper insights into the molecular pathways involving RIMS2, highlighting its importance in neuronal communication and overall brain function.
