Analytical Data
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Gene name
CDH23
- Application
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Alternative Names
DFNB12; USH1D; CDHR23; Otocadherin; Cadherin-Related Family Member 23
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H251
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Expression Region
His34~Phe236
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDH23 (Cadherin 23) is a member of the cadherin superfamily, which plays a critical role in cell adhesion processes and has been extensively studied due to its association with auditory function and hereditary deafness. Mutations in the CDH23 gene are linked to a range of auditory phenotypes, particularly nonsyndromic hearing loss, highlighting its importance in the integrity of the hair cells in the inner ear. The protein is predominantly expressed in sensory cells of the inner ear, where it participates in the formation of the hair cell tip links, essential for mechanoelectrical transduction. Furthermore, CDH23 is implicated in maintaining cell-cell junctions and contributes to the structural organization required for proper auditory signal transduction. Research on recombinant CDH23 protein has gained momentum to investigate its structural and functional dynamics, providing insights into its role in cell adhesion and the molecular mechanisms underlying hearing loss. By generating and analyzing recombinant CDH23, researchers aim to understand its binding properties, interactions with other proteins, and the implications of specific mutations on its function. This knowledge is not only vital for elucidating the pathophysiology of auditory disorders but also holds potential for the development of targeted therapies and diagnostic tools for hearing impairment. The study of CDH23 and its recombinant form represents a crucial intersection of molecular biology, genetics, and audiology, paving the way for advancements in understanding and potentially treating auditory-related conditions.
