Analytical Data
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基因名
DSC2/Desmocollin-2
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简介
DSC2/Desmocollin-2 protein is vital for intercellular desmosome junctions, mediating adhesion by interacting with plaque proteins and intermediate filaments. It also regulates cell positioning and interacts with DSP, PKP2, and JUP, strengthening junction stability. Overall, DSC2/Desmocollin-2 protein maintains tissue organization and functionality. DSC2/Desmocollin-2 Protein, Human (HEK293, C-His) is the recombinant human-derived DSC2/Desmocollin-2, expressed by HEK293, with C-10*His labeled tag. The total length of DSC2/Desmocollin-2 Protein, Human (HEK293, C-His) is 657 a.a..
- Application
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生物活性
Measured by its ability to inhibit the proliferation of PC-3 cells. The ED50 for this effect is 0.8445 μg/mL, corresponding to a specific activity is 1184.13 units/mg. Measured by its ability to inhibit the proliferation of PC-3 cells. The ED50 for this effect is 0.8445 μg/mL, corresponding to a specific activity is 1184.13 units/mg.
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别名
Cadherin family member 2; CDHF2; DSC3; Desmosomal glycoprotein II
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种属
Human
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q02487
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表达区间
A28-R684
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氨基酸序列
ASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPR
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蛋白长度
Partial
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分子量
80-100 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Desmocollin-2 (DSC2) is a member of the desmosomal cadherin family, integral to cell adhesion and the structural integrity of tissues, particularly in the heart and skin. Research on DSC2 has gained prominence due to its critical role in desmosomes, which are intercellular junctions that provide mechanical stability to tissues by anchoring keratin intermediate filaments. Mutations and dysfunctions in DSC2 have been linked to various diseases, including arrhythmogenic right ventricular cardiomyopathy (ARVC) and skin disorders like genodermatoses. The study of DSC2 recombinant proteins is particularly important for elucidating the molecular mechanisms underlying desmosomal function and for developing potential therapeutic strategies. Recombinant DSC2 proteins enable researchers to investigate the protein's structural properties, interactions with other desmosomal components, and its role in cell signaling pathways. Moreover, understanding DSC2's function can provide insights into the pathogenesis of related diseases, contributing to the development of targeted therapies. Overall, research on DSC2 not only enhances our understanding of intercellular adhesion but also holds promise for addressing diseases associated with desmosomal dysfunction.
