Analytical Data
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Gene name
DSC2/Desmocollin-2
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简介
DSC2 (or Desmocollin-2) is an important component of desmosome connections between cells and plays a key role in the complex interaction network between plaque proteins and intermediate filaments. At these junctions, DSC2 contributes to cell-cell adhesion, promoting tissue cohesion and stability. DSC2/Desmocollin-2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived DSC2/Desmocollin-2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Cadherin family member 2; CDHF2; DSC3; Desmosomal glycoprotein II
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Species
Rat
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3T1K6
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Expression Region
C29-P694
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Desmocollin-2 (DSC2) is a member of the desmosomal cadherin family, integral to cell adhesion and the structural integrity of tissues, particularly in the heart and skin. Research on DSC2 has gained prominence due to its critical role in desmosomes, which are intercellular junctions that provide mechanical stability to tissues by anchoring keratin intermediate filaments. Mutations and dysfunctions in DSC2 have been linked to various diseases, including arrhythmogenic right ventricular cardiomyopathy (ARVC) and skin disorders like genodermatoses. The study of DSC2 recombinant proteins is particularly important for elucidating the molecular mechanisms underlying desmosomal function and for developing potential therapeutic strategies. Recombinant DSC2 proteins enable researchers to investigate the protein's structural properties, interactions with other desmosomal components, and its role in cell signaling pathways. Moreover, understanding DSC2's function can provide insights into the pathogenesis of related diseases, contributing to the development of targeted therapies. Overall, research on DSC2 not only enhances our understanding of intercellular adhesion but also holds promise for addressing diseases associated with desmosomal dysfunction.
