Analytical Data
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Gene name
PANK4
- Application
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Alternative Names
Pantothenic acid kinase 4
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NVE7
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Expression Region
Glu639~Glu773
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Molecular Weight
18kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PANK4, or Pantothenate Kinase 4, is an important enzyme in the coenzyme A biosynthesis pathway, playing a crucial role in energy metabolism and maintaining cellular function. It is a member of the pantothenate kinase family and has been implicated in various biological processes, including lipid metabolism and neuronal health. Dysregulation of PANK4 expression has been associated with certain metabolic disorders and neurodegenerative diseases, making it a protein of interest in biomedical research. The recombinant expression of PANK4 allows for the study of its enzymatic activity, regulatory mechanisms, and physiological roles in greater detail. This research is vital for understanding its potential as a therapeutic target. Investigating PANK4's structure-function relationship and interaction with other proteins can provide insights into its involvement in disease pathways. Additionally, the production of PANK4 as a recombinant protein enables further studies, such as structural characterization and the development of inhibitors or activators, which could lead to novel treatments for conditions linked to its dysfunction. Overall, the study of PANK4 and its recombinant form is essential for elucidating its contributions to cellular metabolism and the implications of its dysfunction in health and disease.
