Analytical Data
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Gene name
NLGN4Y
- Application
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NFZ3
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Expression Region
Gln44~Gly254
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NLGN4Y (Neuroligin 4, Y-linked) is a member of the neuroligin family, which consists of proteins known to play crucial roles in synapse formation and maintenance in the central nervous system. Discovered as a gene located on the Y chromosome, NLGN4Y has garnered attention due to its potential involvement in neurodevelopmental disorders, particularly autism spectrum disorders (ASD). The study of NLGN4Y is particularly significant because it reflects the complex interplay between genetic factors and synaptic mechanisms underlying neural connectivity. Emerging evidence suggests that alterations in NLGN4Y expression or function can disrupt synaptic transmission and plasticity, which are integral to cognitive and behavioral processes. With the advent of advanced molecular techniques, researchers are now able to produce recombinant NLGN4Y protein to study its structure, function, and interactions with other synaptic components. This research aims to elucidate the specific roles of NLGN4Y in neuronal circuitry and its contributions to the pathophysiology of neurodevelopmental disorders. By understanding the molecular mechanisms by which NLGN4Y influences synaptic dynamics, scientists hope to provide insights into potential therapeutic strategies for ASD and related conditions. Investigating NLGN4Y not only enhances our understanding of synaptic biology but also opens avenues for developing targeted interventions to mitigate the impact of genetic variations associated with neurodevelopmental disorders.
