Analytical Data
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基因名
NMT1
- Application
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别名
Myristoyl-CoA:protein N-myristoyltransferase 1; Glycylpeptide N-tetradecanoyltransferase 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30419
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表达区间
Met1~Leu222
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分子量
34kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NMT1 (N-myristoyltransferase 1) is an essential enzyme involved in the post-translational modification of proteins through the addition of a myristoyl group, a process that significantly influences protein function, localization, and interactions. The study of NMT1 is particularly relevant in the context of various diseases, including cancer and infectious diseases, as it plays a crucial role in the life cycle of certain pathogens and the signaling pathways of host cells. Research has shown that myristoylation can affect cell signaling, membrane localization, and protein stability, thereby influencing cellular behaviors and disease progression. The recombinant expression of NMT1 allows for detailed investigations into its enzymatic mechanisms, substrate specificity, and potential as a therapeutic target. Moreover, understanding NMT1's role in the myristoylation of key proteins may lead to the development of novel inhibitors that could disrupt pathogenic processes or promote tumor suppression. Consequently, the exploration of NMT1 as a recombinant protein not only enhances our understanding of myristoylation but also opens avenues for innovative strategies in drug development and therapeutic interventions against a range of diseases.
