Analytical Data
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Gene name
NLGN2
- Application
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NFZ4
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Expression Region
Val44~Ser264
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Molecular Weight
53kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NLGN2, or neuroligin 2, is a member of the neuroligin family of proteins, which play a crucial role in synapse formation and function in the nervous system. Neuroligins are known to interact with neurexins and other synaptic proteins, facilitating the establishment of excitatory and inhibitory synapses in the brain. The study of NLGN2 has garnered significant attention due to its implications in various neuropsychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia. Genetic mutations in the NLGN2 gene have been linked to altered synaptic functions, which may contribute to the pathophysiology of these conditions. Understanding the structure and function of NLGN2 at the molecular level can provide insights into the mechanisms underlying synaptic dysfunction and its association with behavioral and cognitive deficits. The development of recombinant NLGN2 proteins allows for detailed biochemical and biophysical studies, enabling researchers to investigate the protein's role in synaptic signaling, its interactive dynamics with neurexins, and its impact on neuronal development and plasticity. Such studies are essential for uncovering potential therapeutic targets and strategies for treating disorders associated with NLGN2 dysfunction. Overall, the research on NLGN2 not only enhances our understanding of synaptic biology but also opens avenues for addressing the complexities of neurodevelopmental and neuropsychiatric diseases.
