Analytical Data
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Gene name
COPT1
- Application
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Alternative Names
SLC31A1; CTR1; hCTR1; High Affinity Copper Uptake Protein 1; Solute Carrier Family 31 Member 1
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Species
Human
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Source
E. coli
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Tag
Two N- s, His- & SUMO-
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15431
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Expression Region
Met1~ Leu61
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Molecular Weight
25kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COPT1, a copper transporter identified in various organisms, is crucial for maintaining copper homeostasis in cells. As essential micronutrients, copper ions play vital roles in enzymatic reactions, mitochondrial function, and cellular metabolism; however, excess copper can lead to toxicity. Understanding the structure and function of COPT1 is significant for elucidating the mechanisms of copper transport and regulation within the cell. The study of COPT1 recombination protein has gained attention due to its implications for human health, particularly concerning disorders like Wilson's disease, which is characterized by copper accumulation in tissues, and Menkes disease, marked by impaired copper absorption. Recent research efforts focus on the protein’s expression, purification, and functional characterization to explore its transport mechanisms and interaction with other cellular components. Additionally, insights into COPT1 may inform therapeutic strategies for managing copper-related diseases and contribute to biotechnological applications in agriculture and industry. Understanding the molecular details and regulatory networks involving COPT1 can pave the way for novel approaches in treating copper imbalances and understanding the broader implications of trace metal homeostasis in living organisms.
