Analytical Data
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Gene name
TAT1
- Application
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Alternative Names
SLC26A8; Solute Carrier Family 26 Member 8; Anion exchange transporter
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96RN1
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Expression Region
Thr664~Val970
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Molecular Weight
65kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TAT1, or Transporter Associated with Antigen Processing 1, is a protein that plays a crucial role in the immune response by facilitating the transport of peptides into the endoplasmic reticulum, where they are loaded onto MHC class I molecules for presentation to CD8+ T cells. The study of TAT1 has gained significant attention due to its implications in autoimmune diseases, cancer immunotherapy, and the understanding of peptide-MHC interactions. Researchers are particularly interested in its potential as a therapeutic target, as manipulating TAT1 expression or function could enhance the efficacy of vaccines and immunotherapies by improving antigen presentation. Moreover, TAT1 has been implicated in various cellular processes beyond antigen processing, including the regulation of cellular stress responses and apoptosis. The recombinant production of TAT1 has enabled detailed biochemical and biophysical characterization, allowing scientists to explore its structure-function relationships and develop inhibitors or modulators with potential clinical applications. Understanding the mechanisms that govern TAT1's activity could provide insights into immune evasion by tumors and other pathological conditions, paving the way for novel treatment strategies that harness the body's immune system more effectively. Thus, the ongoing research into TAT1 recombinant proteins not only contributes to fundamental immunological knowledge but also has the potential to translate into significant advancements in therapeutic interventions.
