Analytical Data
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Gene name
PCDH18
- Application
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Alternative Names
PCDH68L
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8VHR0
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Expression Region
Phe378~Asp607
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDH18, a member of the protocadherin family, plays a crucial role in cell-cell adhesion and signaling in the nervous system. Emerging research has highlighted its significance in neurodevelopment and potential implications in various neuropsychiatric disorders due to its involvement in synaptic formation and plasticity. Structurally, PCDH18 is characterized by multiple extracellular cadherin domains that facilitate homophilic interactions, critical for maintaining cellular architecture and communication in neuronal tissues. Studies investigating the recombinant expression of PCDH18 have aimed to elucidate its functional properties and interactions with other neuronal proteins, shedding light on its mechanisms in synaptic dynamics. Furthermore, understanding the role of PCDH18 in pathological conditions can pave the way for novel therapeutic strategies. The recombinant protein serves as a valuable tool for exploring these interactions in vitro, providing insights into how disruptions in PCDH18 may contribute to the etiology of disorders like schizophrenia and autism spectrum disorders. Overall, the research on PCDH18 recombinant protein not only advances our understanding of fundamental neuronal processes but also holds promise for translational applications in neurobiology.
