Analytical Data
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基因名
MAP2K1
- Application
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别名
MAPKK1; MEK1; MKK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02750
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表达区间
Leu54~Val369
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分子量
38kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP2K1, also known as MEK1, is a crucial dual-specificity kinase that plays a significant role in the MAPK/ERK signaling pathway, which is essential for various cellular processes, including proliferation, differentiation, and survival. Abnormalities in MAP2K1, often associated with mutations or amplifications, have been implicated in various cancers, making it a significant focus of oncological research. The functional study of MAP2K1, particularly its recombinant protein, holds promise not only for understanding its role in tumorigenesis but also for developing targeted therapies. Recombinant MAP2K1 allows researchers to investigate its biochemical properties, interactions with other proteins, and potential as a therapeutic target more effectively. Additionally, studying MAP2K1 in a recombinant form can aid in the identification of specific inhibitors that could be beneficial in treating MAPK pathway-related diseases. Given the complexity of signaling pathways in cancer, MAP2K1 serves as a pivotal molecule, making its in-depth analysis vital for advancing cancer research and treatment strategies.
