Analytical Data
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基因名
MAP3K6
- Application
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别名
MAPKKK6; ASK2; MEKK6; Apoptosis Signal Regulating Kinase 2
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
D3ZFL3
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表达区间
Thr649~Leu907
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP3K6, also known as mitogen-activated protein kinase kinase kinase 6, is a member of the MAPK signaling pathway that plays a critical role in regulating various cellular processes including proliferation, differentiation, and apoptosis. Its expression and activity have been implicated in several diseases, particularly cancer, where aberrant MAPK signaling is a hallmark of tumorigenesis. Research into MAP3K6 has shown that it can activate downstream MAPK pathways, influencing cell survival and resistance to therapy. Given its regulatory role, MAP3K6 is increasingly being studied not only for its biological functions but also as a potential therapeutic target. The recombinant expression of MAP3K6 allows researchers to investigate its structure, function, and interaction with other proteins, providing insights into its role in cellular signaling networks. Moreover, understanding the structural characteristics and functional mechanisms of MAP3K6 can aid in the development of targeted therapies that could mitigate its contribution to disease progression. Overall, the study of recombinant MAP3K6 is vital for elucidating its role in normal physiology and its involvement in pathological conditions, potentially leading to novel therapeutic strategies.
