Analytical Data
-
Gene name
NR4A2
- Application
-
Alternative Names
Immediate-early response protein NOT Orphan nuclear receptor NURR1 Transcriptionally-inducible nuclear receptor NOT, NURR1, TINUR
-
Species
Human
-
Source
Yeast
-
Tag
N- His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P43354
-
Expression Region
1-598aa
-
Molecular Weight
68.6 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NR4A2, also known as Nuclear Receptor Subfamily 4 Group A Member 2, is a transcription factor that belongs to the nuclear receptor family, playing a pivotal role in various biological processes, including neurodevelopment, metabolism, and immune response. Research has increasingly focused on NR4A2 due to its involvement in neurodegenerative diseases, particularly Parkinson's disease, where its expression is altered and linked to neuronal survival and apoptosis. Furthermore, NR4A2 is implicated in the regulation of several genes related to inflammation and oxidative stress, making it a potential target for therapeutic interventions. As a result, the study of NR4A2 recombinant proteins has garnered significant interest, as these proteins can be utilized to elucidate its mechanisms of action, interactions with other cellular components, and regulatory pathways. Understanding NR4A2 function at a molecular level may lead to the development of novel treatments aimed at restoring its activity or mitigating its dysregulation in disease states. The use of recombinant NR4A2 also facilitates high-throughput screening of small molecules that could modulate its activity, opening avenues for drug discovery and contributing to the growing field of targeted therapy in neurodegenerative and inflammatory diseases.
