Analytical Data
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Gene name
PKD3
- Application
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Alternative Names
PRKD3; EPK2; PKC-NU; PRKCN; nPKC-NU; Protein Kinase C,Nu
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94806
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Expression Region
Ile576~Leu832
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PKD3 (Protein Kinase D3) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. It is part of the PKD family, which is involved in numerous signaling pathways, particularly those related to cancer progression and immune responses. Research on PKD3 has gained momentum due to its potential implications in diseases such as cancer, where it may act as a tumor promoter or suppressor depending on the context. Understanding the structure and function of PKD3 is essential for developing targeted therapies, as aberrant PKD3 activity has been linked to several malignancies and other health issues. Recent studies have focused on the generation of recombinant PKD3 proteins to elucidate its mechanism of action, interactions with other signaling molecules, and regulation under various physiological conditions. This research aims to provide insights into PKD3's role in cellular signaling and highlight its potential as a therapeutic target in oncology and other diseases. As recombinant proteins offer advantages for functional assays, such as studying enzyme kinetics and inhibitor screening, the investigation of PKD3 through these methodologies is pivotal for advancing our understanding of this kinase's contribution to human health and disease.
