Analytical Data
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Gene name
RLN1/Relaxin-1
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简介
The RLN1/Relaxin-1 protein is an important ovarian hormone that cooperates with estrogen to induce birth canal dilation. It plays a vital role in connective tissue remodeling during pregnancy, promoting pubic ligament growth and cervical ripening. RLN1/Relaxin-1 Protein, Human (HEK293, His) is the recombinant human-derived RLN1/Relaxin-1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
Measured by its ability to induce cAMP accumulation in THP-1 human acute monocytic leukemia cells. The ED50 for this effect is 10.95 ng/mL, corresponding to a specific activity is 9.132×104 U/mg. Measured by its ability to induce cAMP accumulation in THP-1 human acute monocytic leukemia cells. The ED50 for this effect is 10.95 ng/mL, corresponding to a specific activity is 9.132×104 U/mg.
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Alternative Names
Prorelaxin H1; RLN1; RLXH1
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04808
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Expression Region
V23-C185
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Protein Length
Full Length of Mature Protein
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Molecular Weight
20 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Relaxin-1 (RLN1) is a peptide hormone belonging to the relaxin family, primarily known for its roles in reproductive biology and cardiovascular function. Initially identified for its involvement in pregnancy, where it facilitates uterine remodeling and prepares the reproductive tract for childbirth, RLN1 is also implicated in various physiological processes beyond reproduction, including kidney function, tissue remodeling, and anti-fibrotic effects. The therapeutic potential of RLN1 has garnered significant interest, especially in the context of heart failure and other cardiovascular diseases, where it's thought to exert positive effects by promoting vasodilation, reducing hypertension, and modulating renal function. Research has focused on the recombinant expression of RLN1 to harness its therapeutic benefits, allowing for more extensive studies on its biological functions and mechanisms. The production of recombinant RLN1 proteins enables standardized dosing and enhances our understanding of its pharmacological properties, paving the way for future clinical applications. As the field of therapeutic peptides continues to evolve, the exploration of RLN1 not only expands our comprehension of its biological significance but also offers promising avenues for novel treatment strategies aimed at various health conditions.
