Analytical Data
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Gene name
KREMEN1
- Application
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Alternative Names
KRM1; KREMEM1; Dickkopf receptor; Kringle-containing protein marking the eye and the nose
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96MU8
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Expression Region
Lys157~Gly390
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KREMEN1, a member of the Kremen protein family, has garnered interest in the field of molecular biology due to its significant role in regulating key signaling pathways, particularly those related to Wnt signaling and the development of various tissues. KREMEN1 acts as a receptor for Dickkopf proteins, which antagonize Wnt signaling, thereby influencing processes such as cell proliferation, differentiation, and apoptosis. Understanding KREMEN1's function is crucial, as dysregulation of Wnt signaling has been implicated in numerous diseases, including cancer and developmental disorders. Recent studies have suggested that KREMEN1 may play a role in stem cell biology and tissue regeneration, making it a potential target for therapeutic interventions. Research focusing on the recombinant expression of KREMEN1 protein aims to elucidate its structural and functional properties, facilitate the development of KREMEN1-targeted treatments, and provide insights into its interaction with Wnt pathway components. By producing recombinant KREMEN1, scientists can conduct in-depth analyses of its molecular mechanisms, paving the way for novel strategies in regenerative medicine and oncology.
