Analytical Data
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Gene name
KPNa3
- Application
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Alternative Names
KPN-A3; IPOA4; Qip2; SRP1gamma; SRP4; hSRP1; Importin Alpha 4; Importin alpha Q2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00505
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Expression Region
Glu3~Val220
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Molecular Weight
28kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of KPNa3 recombinant protein centers on its role as a nucleocytoplasmic transport receptor, which is crucial for the movement of proteins and RNA between the nucleus and cytoplasm in eukaryotic cells. Understanding KPNa3 is pertinent because it facilitates the import of important biomolecules, influencing various cellular processes, including gene expression and cell signaling. Disruptions in the function of KPNa3 have been associated with several diseases, including cancer, making it a promising target for therapeutic interventions. Recent advancements in recombinant protein technology have enabled scientists to produce KPNa3 in significant quantities, allowing for detailed structural and functional analyses. These studies aim to elucidate the molecular mechanisms underlying its transport function, to explore its interactions with other cellular components, and to assess its potential as a biomarker for disease. Additionally, researchers are investigating the utilization of KPNa3-based systems in drug delivery and gene therapy, as manipulating its transport capabilities could enhance the efficacy of treatments. Overall, the research on KPNa3 recombinant protein not only sheds light on fundamental cellular mechanisms but also opens new avenues for clinical applications, highlighting its significance in both basic and applied sciences.
