Analytical Data
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Gene name
HE4/WFDC2
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简介
HE4/WFDC2 protein is a disulfide-bonded homotrimer serving as a broad range protease inhibitor. HE4/WFDC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HE4/WFDC2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
WAP four-disulfide core domain protein 2; HE4; WFDC2
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9DAU7
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Expression Region
T26-F174
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Protein Length
Full Length of Mature Protein
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Molecular Weight
23-30 kDa. Glycosylation sites are found in mouse HE4/WFDC2 protein.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HE4, also known as WFDC2, is a protein that has garnered significant attention in the field of cancer research, particularly in relation to ovarian cancer. Initially discovered as a potential biomarker for this malignancy, HE4 is involved in the regulation of inflammatory processes and has been implicated in various conditions beyond cancer, including respiratory diseases. Research has shown that HE4 levels can be elevated in ovarian cancer patients, making it a valuable tool for diagnosis and monitoring disease progression. Despite its clinical relevance, the precise biological function of HE4 remains poorly understood. Recombining HE4/WFDC2 into a recombinant protein opens avenues for detailed study of its structure, function, and interactions at a molecular level. This research not only aims to elucidate the role of HE4 in cancer biology but also seeks to explore its potential therapeutic applications. Employing recombinant technology facilitates the production of large quantities of the protein, allowing for in-depth investigations, including binding affinity studies and functional assays, which can lead to the development of targeted therapeutics or novel diagnostic methods. This area of study is crucial, as understanding HE4's mechanism of action could provide insights into the pathophysiology of ovarian cancer, ultimately improving patient outcomes through more personalized medical approaches.
