Analytical Data
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Gene name
HOXA1
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简介
The HOXA1 protein is a sequence-specific transcription factor that complexly regulates multiple developmental processes in the brainstem, inner and outer ears, abducens nerves, and cardiovascular development. It also plays a key role in cognitive and behavioral processes. HOXA1 Protein, Human (His) is the recombinant human-derived HOXA1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Homeobox protein Hox-A1; HOXA1; HOX1F
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49639-1
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Expression Region
M1-H335
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Protein Length
Full Length of Isoform-1
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Molecular Weight
42 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXA1 is a member of the homeobox gene family, which plays a crucial role in embryonic development and cellular differentiation. Research has shown that HOXA1 is involved in various biological processes, including the regulation of development in the central nervous system, limb formation, and hematopoiesis. Dysregulation of HOXA1 expression has been implicated in several diseases, particularly cancers and neurodevelopmental disorders. As a transcription factor, HOXA1 functions by binding to specific DNA sequences, thereby influencing the expression of downstream target genes. Understanding the molecular mechanisms of HOXA1 activity is essential for elucidating its role in normal development and disease. The production of recombinant HOXA1 protein allows for detailed biochemical studies, including its interaction with other proteins and its functionality in various cellular contexts. By characterizing the structure and function of HOXA1, researchers aim to uncover its potential as a therapeutic target and its contributions to pathophysiological conditions. The study of HOXA1 recombinant protein forms a vital foundation for advancing our knowledge of developmental biology and therapeutic interventions for HOXA1-related diseases.
