Analytical Data
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Gene name
KLC1
- Application
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Alternative Names
KLC; KNS2; KNS2A; hKLC1S; hKLC1N; hKLC1P; hKLC1G; hKLC1R; hKLC1J; hKLC1B; Kinesin 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q07866
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Expression Region
Met1~Val254
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Molecular Weight
40kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLC1, or Kinesin Light Chain 1, is a crucial component of the kinesin motor protein family, which plays a significant role in intracellular transport. The kinesin proteins are essential for the movement of organelles, vesicles, and other cargo along microtubules, facilitating various cellular processes such as mitosis, neurotransmitter release, and cytoskeletal organization. The study of KLC1 is particularly important due to its involvement in neurobiology and potential implications in neurodegenerative diseases. Research has shown that KLC1 interacts with various cargo proteins and is involved in transporting them to their specific destinations within the cell. Additionally, mutations or dysregulation of KLC1 are linked to several pathologies, including neurological disorders. As a result, understanding the structure and function of KLC1, especially through the study of recombinant proteins, has become increasingly relevant. Recombinant KLC1 proteins can serve as valuable tools for elucidating the mechanisms of kinesin-mediated transport, providing insights into the molecular interactions that underpin cellular function. Moreover, these studies can help identify potential therapeutic targets for diseases associated with kinesin dysfunction, enhancing our understanding of cell biology and paving the way for innovative treatment strategies.
