Analytical Data
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基因名
AFG3L2
- Application
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别名
Paraplegin-like protein
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y4W6
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表达区间
550-759aa
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分子量
50.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AFG3L2, also known as ATP-dependent protease AFG3-like 2, is a mitochondrial protein that plays a crucial role in protein quality control and the regulation of mitochondrial function. Its significance has been underscored in various studies linking mutations in the AFG3L2 gene to neurodegenerative diseases, particularly spinocerebellar ataxia type 28 (SCA28) and other forms of ataxia. As a member of the AAA+ (ATPases Associated with diverse cellular Activities) family, AFG3L2 is involved in the degradation of misfolded proteins within the mitochondria, thus maintaining mitochondrial integrity and functionality. The understanding of AFG3L2's structure and function has been enhanced through recombinant protein studies, which aid in elucidating its enzymatic mechanisms and interactions with other mitochondrial proteins. Furthermore, given its association with mitochondrial disorders, AFG3L2 is a potential target for therapeutic interventions aimed at ameliorating mitochondrial dysfunction. Research on AFG3L2 not only sheds light on the molecular pathways involved in mitochondrial diseases but also contributes to broader insights into cellular homeostasis and the aging process.
