Analytical Data
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基因名
PTPRF
- Application
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别名
PTPR-F; LAR; Leukocyte common antigen related
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10586
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表达区间
Asp30~Tyr224
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分子量
27kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTPRF, or protein tyrosine phosphatase receptor type F, is a member of the receptor-type phosphatase family, which plays a crucial role in cellular signaling and processes such as cell growth, differentiation, and adhesion. The dysregulation of PTPRF has been implicated in various pathologies, including cancer and autoimmune diseases, making it a significant target for therapeutic intervention. Research on PTPRF has focused on its structure-function relationships, signaling pathways, and interactions with other membrane proteins. Its ability to dephosphorylate specific tyrosine residues is essential for modulating receptor activity and downstream signaling cascades, thus influencing various biological processes. Recombinant PTPRF proteins are being developed to better understand these mechanisms and to evaluate their potential in drug design. By producing and characterizing these proteins, researchers aim to elucidate the role of PTPRF in health and disease, paving the way for novel therapeutic strategies targeting this phosphatase. Through advanced techniques such as crystallography and molecular modeling, insights into the enzymatic activity and regulatory mechanisms of PTPRF can be gained, ultimately contributing to a deeper understanding of its biological significance and potential clinical applications.












