Analytical Data
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Gene name
PTPRF
- Application
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Alternative Names
PTPR-F; LAR; Leukocyte common antigen related
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10586
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Expression Region
Asp30~Tyr224
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTPRF, or protein tyrosine phosphatase receptor type F, is a member of the receptor-type phosphatase family, which plays a crucial role in cellular signaling and processes such as cell growth, differentiation, and adhesion. The dysregulation of PTPRF has been implicated in various pathologies, including cancer and autoimmune diseases, making it a significant target for therapeutic intervention. Research on PTPRF has focused on its structure-function relationships, signaling pathways, and interactions with other membrane proteins. Its ability to dephosphorylate specific tyrosine residues is essential for modulating receptor activity and downstream signaling cascades, thus influencing various biological processes. Recombinant PTPRF proteins are being developed to better understand these mechanisms and to evaluate their potential in drug design. By producing and characterizing these proteins, researchers aim to elucidate the role of PTPRF in health and disease, paving the way for novel therapeutic strategies targeting this phosphatase. Through advanced techniques such as crystallography and molecular modeling, insights into the enzymatic activity and regulatory mechanisms of PTPRF can be gained, ultimately contributing to a deeper understanding of its biological significance and potential clinical applications.
