Analytical Data
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基因名
HTR1A
- Application
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别名
5HTR1A; 5HTR1-A; 5-HTR1-A; ADRB2RL1; ADRBRL1; Serotonin Receptor 1A
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08908
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表达区间
Ile218~Lys345
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分子量
20kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HTR1A, also known as the 5-HT1A receptor, is a subtype of the serotonin receptor family that plays a crucial role in neurotransmission and modulating various neurophysiological processes, including mood regulation, anxiety, and cognition. Dysregulation of HTR1A has been implicated in several neuropsychiatric disorders, such as depression and schizophrenia, making it a significant target for therapeutic intervention. In recent years, extensive research has focused on the structural and functional properties of the HTR1A receptor, particularly through the production of recombinant proteins. Recombinant HTR1A proteins allow for detailed pharmacological studies and the exploration of receptor interactions with ligands, both agonists and antagonists. Understanding the receptor’s conformational changes and signaling pathways is vital for the development of new drugs aimed at modulating its activity. Advances in techniques such as X-ray crystallography and cryo-electron microscopy have significantly enhanced our ability to visualize HTR1A's structure at the molecular level, providing insights into its mechanism of action. Overall, the study of HTR1A recombinant proteins is integral to uncovering the complexities of serotonin signaling and paves the way for novel therapeutic strategies to address related mental health disorders.
