Analytical Data
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Gene name
FGFR-1 beta (IIIc)
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简介
FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 beta (IIIc) Protein, Human (HEK293, His-Avi) is the recombinant human-derived FGFR-1 beta, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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Biological Activity
1.Immobilized Anti-FGFR1 Anitibody, hFc Tag at 2 μg/mL (100 μl/Well)on the plate. Dose response curve for Human FGFR1 beta (Illc), His Tag with the EC50 of ≤ 0.34 μg/mL determined by ELISA. 2.Immobilized Human FGFR1 beta (IIIc) at 0.5 μg/mL (100 μL/Well) on the plate. Dose response curve for Anti-FGFR1 Antibody with the ED50 of 0.3177 μg/mL determined by ELISA. Immobilized Human FGFR1 beta (IIIc) at 0.5 μg/mL (100 μL/Well) on the plate. Dose response curve for Anti-FGFR1 Antibody with the ED50 of 0.3177 μg/mL determined by ELISA.
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Alternative Names
Fibroblast growth factor receptor 1; FGFR-1; BFGFR; bFGF-R-1; FLT-2; CD331;
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P11362-7
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Expression Region
K158-T355
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AA Sequence
KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLT
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Protein Length
Partial
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Molecular Weight
40-55 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast Growth Factor Receptor 1 (FGFR-1) plays a crucial role in various biological processes, including cell proliferation, differentiation, and angiogenesis. The receptor exists in several isoforms, with FGFR-1 beta (IIIc) being particularly significant in the context of cancer biology. This isoform has been linked to tumorigenesis, as it is often over-expressed in various malignancies and is associated with tumor growth and metastasis. Research has shown that FGFR-1 beta (IIIc) mediates signaling pathways that promote cancer cell survival and invasiveness, making it a potential therapeutic target. The development of recombinant FGFR-1 beta (IIIc) proteins allows for detailed investigations into its structure, function, and interactions with ligands. Such studies are essential for the validation of FGFR-1 beta (IIIc) as a biomarker for cancer diagnostics and as a target for novel treatment strategies. Understanding the molecular mechanisms underlying its role in cancer may provide insights into new therapies that can inhibit its function, thereby offering hope for improved outcomes in cancer treatment.
