Analytical Data
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基因名
FGFR-1 alpha (IIIc)
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简介
FGFR-1 alpha is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical in embryonic development, cell proliferation, differentiation, and migration. GnRH is essential for mesodermal patterning, axial organization, skeletogenesis, and nervous system development. FGFR-1 alpha (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-1 alpha, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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别名
FGF R1a; FGFR1 alpha
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11362-7
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表达区间
R22-E374
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蛋白长度
Extracellular Domain
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分子量
65-90 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast Growth Factor Receptor 1 (FGFR1) plays a critical role in various biological processes including embryonic development, cell proliferation, and tissue repair. The FGFR1 α (IIIc) isoform, a specific variant of this receptor, is particularly important in mediating the actions of fibroblast growth factors (FGFs) in vascular development, bone formation, and wound healing. Dysregulation of FGFR1 signaling has been implicated in several pathologies, including cancer, where aberrant FGFR1 activity may contribute to tumor growth, metastasis, and resistance to therapy. Given its significant role in tumor biology, FGFR1 α (IIIc) has emerged as a potential target for therapeutic intervention. Research aims to elucidate the molecular mechanisms underpinning FGFR1 α (IIIc) functions and its interactions with specific ligands, as well as to develop recombinant protein studies that could pave the way for novel treatment strategies. Advances in recombinant technology allow for the production of purified FGFR1 α (IIIc) proteins that can be used in various assays, providing insights into receptor signaling pathways and facilitating drug discovery efforts in malignancies associated with FGFR dysregulation. This research background highlights the importance of FGFR1 α (IIIc) as a focal point in understanding both fundamental cellular processes and the development of innovative therapeutic approaches.
