Analytical Data
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Gene name
COL11a2
- Application
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Alternative Names
COL11-A2; DFNA13; DFNB53; HKE5; Collagen Alpha-2(XI)chain
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13942
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Expression Region
Met1~Gln266
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Molecular Weight
38kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL11A2, a type of collagen, is primarily expressed in various tissues during development and plays a crucial role in the formation of extracellular matrix structures. Its specific involvement in cartilage formation and maintenance has been of substantial interest in the context of skeletal disorders, particularly in conditions like osteoarthritis and chondrodysplasias. Research has shown that mutations in the COL11A2 gene can lead to significant abnormalities in the collagen structure, impacting the integrity and functionality of cartilage tissue. The recombinant COL11A2 protein has emerged as a valuable tool for studying the molecular mechanisms underlying cartilage development and degeneration. By generating this protein through recombinant DNA technology, researchers can explore its biochemical properties, interactions with other extracellular matrix components, and its role in cellular behaviors such as proliferation and differentiation of chondrocytes. Moreover, recombinant COL11A2 can serve as a potential candidate for tissue engineering applications, offering insights into the development of regenerative therapies for cartilage repair. Thus, studies involving COL11A2 recombinant protein are pivotal for advancing our understanding of cartilage biology and developing innovative approaches to combat cartilage-related diseases.
