Analytical Data
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基因名
NDUFB7
- Application
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别名
Cell adhesion protein SQM1Complex I-B18 ;CI-B18NADH-ubiquinone oxidoreductase B18 subunit
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种属
Human
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表达系统
E. coli
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标签
N- GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P17568
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表达区间
2-137aa
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分子量
43.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NDUFB7, a crucial component of the mitochondrial respiratory chain, plays an essential role in the function of complex I, which is responsible for the NADH:ubiquinone oxidoreductase activity. This enzyme complex is fundamental for ATP production through oxidative phosphorylation, making it vital for cellular energy metabolism. Research has shown that mutations in the NDUFB7 gene can lead to severe mitochondrial diseases, resulting in a range of clinical manifestations including neurological disorders, muscle weakness, and organ dysfunction. Understanding the structure and function of NDUFB7 is therefore critical for elucidating the mechanisms of mitochondrial dysfunction and developing potential therapeutic interventions. Recombinant NDUFB7 proteins are increasingly used in biochemical and structural studies to investigate their interactions with other mitochondrial components, the effects of pathological mutations, and the overall assembly of complex I. By generating and characterizing these recombinant proteins, researchers aim to provide insights into the intricacies of mitochondrial energy metabolism, paving the way for advancements in treating related disorders. The ongoing study of NDUFB7 also highlights the importance of mitochondrial health in aging and various metabolic conditions, emphasizing the need for continued exploration of this protein's role in mitochondrial biology.
