Analytical Data
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Gene name
ADCY4
- Application
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Alternative Names
ATP pyrophosphate-lyase 4; Adenylate cyclase type IV
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q91WF3
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Expression Region
Ile352~Val541
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADCY4, or Adenylate Cyclase 4, is a crucial enzyme involved in the synthesis of cyclic adenosine monophosphate (cAMP), a secondary messenger that plays a significant role in various physiological processes such as neurotransmission, hormonal signaling, and metabolic regulation. Elevated interest in ADCY4 has emerged due to its association with several diseases, including heart failure, diabetes, and neurological disorders. Research has shown that ADCY4 can be modulated by G-protein coupled receptors (GPCRs), leading to diverse cellular responses. The recombinant expression of ADCY4 allows for a detailed investigation of its enzymatic activity, regulation, and interaction with other proteins and signaling pathways. Moreover, producing ADCY4 as a recombinant protein enables the exploration of its therapeutic potential, including the development of specific inhibitors or activators that could be used in treating conditions linked to dysregulated cAMP signaling. By elucidating the structure-function relationships of ADCY4 through techniques such as X-ray crystallography and molecular modeling, researchers aim to design novel drugs that can selectively target ADCY4, thereby contributing to more effective therapeutic strategies for associated diseases. Overall, the study of ADCY4 recombinant protein serves as a foundational step in understanding its role in cellular signaling and developing innovative treatments.
