Analytical Data
-
Gene name
ADCY3
- Application
-
Alternative Names
AC3; ATP pyrophosphate-lyase 3; Adenylate cyclase, olfactive type; Adenylate cyclase type III
-
Species
Human
-
Source
E. coli
-
Tag
N- His & GST
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O60266
-
Expression Region
Lys501~Asn736
-
Molecular Weight
56kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADCY3, or adenylate cyclase 3, is a key enzyme involved in the regulation of cyclic adenosine monophosphate (cAMP) levels in cells, playing a crucial role in various physiological processes including neuronal signaling, regulation of metabolism, and cardiovascular function. Mutations and dysregulation of ADCY3 have been implicated in various obesity-related conditions, neurodevelopmental disorders, and other metabolic syndromes, making it a significant focus of biomedical research. Understanding the structure and function of ADCY3, particularly through the study of recombinant protein expressed in vitro, can provide insights into its mechanistic pathways and potential therapeutic targets. The production of recombinant ADCY3 proteins allows researchers to explore the enzyme's biochemical properties, interactions with other signaling molecules, and its role in mediating physiological responses. Additionally, studying ADCY3 in cellular models may help unravel its contributions to disease states, which is pivotal for drug discovery and the development of targeted therapies for related conditions. Overall, the exploration of ADCY3's functional dynamics through recombinant protein studies holds promise for advancing our understanding of cAMP signaling and its implications in health and disease.
