Analytical Data
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Gene name
DRD4
- Application
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Alternative Names
DR-D4; D4R; D4DR; D(2C) dopamine receptor
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P30729
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Expression Region
Met1~Asp106
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Molecular Weight
15&24kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Dopamine receptor D4 (DRD4) is a member of the dopamine receptor family and is primarily known for its role in the modulation of neurotransmission, particularly in relation to behaviors such as attention, mood, and reward. The DRD4 gene has garnered significant interest due to its association with various psychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), schizophrenia, and certain personality traits. Research has identified polymorphisms in the DRD4 gene, particularly the variable number tandem repeat (VNTR) polymorphisms in the third exon, which have been linked to individual differences in behavior and susceptibility to these disorders. However, the mechanisms by which these genetic variations influence receptor function and contribute to behavioral phenotypes remain insufficiently understood. To address this gap, the study of recombinant DRD4 proteins has become a pivotal approach in elucidating the receptor’s structure-function relationships. By expressing and purifying DRD4 in heterologous systems, researchers can analyze how specific mutations affect receptor signaling, ligand binding, and other functional properties. This research not only enhances our understanding of DRD4's biological significance but also has potential implications for the development of targeted therapies for disorders involving dopaminergic dysregulation. Overall, the investigation of DRD4 recombinant proteins is crucial for advancing both basic neuroscience and the translational aspects of neuropsychiatric research.
