Analytical Data
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Gene name
CRBN-DDB1
- Application
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Alternative Names
Protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa
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Species
Human
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Source
Baculovirus
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Tag
Avi
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96SW2-1 (M1-L442) &Q16531-1
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Expression Region
Q96SW2-1 (M1-L442) &Q16531-1 (M1-H1140)
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Molecular Weight
52.6 KDa&126.9 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GAK (Cyclin G-associated kinase) is a serine/threonine kinase that has garnered interest in the fields of cell biology and genetics due to its roles in various cellular processes, including cell cycle regulation, differentiation, and signaling pathways. Research has revealed that GAK plays a crucial role in the regulation of clathrin-mediated endocytosis and is implicated in the development of certain cancers and neurological disorders. The reconstitution of GAK protein provides a valuable tool for studying its biochemical properties, functional mechanisms, and interactions with other cellular proteins. By producing GAK in a controlled laboratory environment, researchers can explore its role in cellular processes at a molecular level, investigate potential post-translational modifications, and identify binding partners that may influence its activity. Furthermore, gaining insights into GAK’s function could unveil novel therapeutic targets for diseases associated with its dysregulation. Thus, the study of GAK recombined protein is not only important for understanding basic cellular mechanisms but also holds promise for contributing to the development of effective strategies in combating various diseases, including cancers and neurodegenerative conditions. This research area highlights the significance of protein reconstitution methodologies in elucidating the role of key regulatory proteins in cellular homeostasis.
