Analytical Data
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基因名
INSR
- Application
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别名
CD220; ISR; HHF5; IR
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P06213
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表达区间
Pro622~Thr945
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分子量
60kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INSR (Insulin Receptor) is a critical protein that plays a vital role in glucose homeostasis and cellular metabolism, as it mediates the physiological effects of insulin. Dysregulation of INSR signaling is implicated in various metabolic disorders, including insulin resistance and type 2 diabetes. The study of recombinant INSR proteins has gained significant attention due to their potential applications in drug discovery and disease modeling. Researchers are focused on expressing and purifying INSR in various systems to study its structure, function, and interaction with insulin, as well as to investigate the effects of mutations associated with insulin resistance. Recombinant INSR proteins provide a valuable tool for elucidating the molecular mechanisms underlying insulin signaling pathways and developing therapeutic strategies to target metabolic diseases. Furthermore, these studies can lead to the design of novel insulin analogs or INSR-targeted therapies that could improve the management of diabetes and related conditions. Overall, the research on recombinant INSR proteins is crucial in addressing the growing global burden of metabolic diseases and enhancing our understanding of insulin signaling.
