Analytical Data
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基因名
ELAVL1
- Application
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别名
ELAV-like protein 1; Hu-antigen R; HuR
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种属
Human
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表达系统
E. coli
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标签
C-Flag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15717-1
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表达区间
S2-K326
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ELAVL1, also known as HuR, is an RNA-binding protein that plays a crucial role in post-transcriptional regulation of gene expression. Its primary function involves stabilizing mRNA transcripts, thereby influencing the expression levels of various genes associated with cell proliferation, differentiation, and stress responses. Given its significant role in regulating mRNA stability and translation, ELAVL1 has been implicated in several pathological conditions, including cancer, neurodegenerative diseases, and inflammatory disorders. Research has demonstrated that elevated levels of ELAVL1 are often associated with tumor progression and increased cell survival, making it a potential therapeutic target. The study of ELAVL1 recombinant proteins allows researchers to dissect its functions, elucidate its binding mechanisms with RNA, and explore its interactions with other cellular factors. By generating and characterizing recombinant ELAVL1, scientists aim to understand how post-transcriptional regulation contributes to cell fate decisions and how dysregulation of this protein can lead to disease. Insights gained from such studies could pave the way for the development of novel therapeutic strategies targeting ELAVL1 in various biomedical contexts.
