Analytical Data
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基因名
CK16
- Application
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别名
KRT16; NEPPK; Keratin 16; Focal Non-Epidermolytic Palmoplantar Keratoderma; Keratin, type I cytoskeletal 16
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08779
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表达区间
Glu117~Arg419
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分子量
39kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CK16 recombinant protein is a key subject of research due to its potential applications in understanding skin biology and developing therapeutics for various dermatological conditions. CK16, or cytokeratin 16, is a type of intermediate filament protein predominantly expressed in the epidermis, particularly in areas subjected to mechanical stress, such as palms and soles. Elevated levels of CK16 are associated with hyperproliferative skin disorders, including psoriasis and eczema, making it a valuable biomarker for these conditions. Research on CK16 recombinant protein involves studying its role in cellular processes such as differentiation, proliferation, and response to injury, which are critical for maintaining skin integrity and function. Furthermore, the production of CK16 in recombinant form allows scientists to investigate its properties in vitro, facilitating the exploration of its interactions with other proteins and cellular components. By elucidating the molecular mechanisms governing CK16 function, researchers aim to develop targeted therapies that could modulate its activity in pathological conditions, ultimately leading to innovative treatments for skin diseases. Overall, the study of CK16 recombinant protein not only enhances our understanding of keratinocyte biology but also holds promise for advancing dermatological science and improving patient outcomes.
