Analytical Data
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Gene name
CK16
- Application
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Alternative Names
KRT16; NEPPK; Keratin 16; Focal Non-Epidermolytic Palmoplantar Keratoderma; Keratin, type I cytoskeletal 16
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08779
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Expression Region
Glu117~Arg419
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Molecular Weight
39kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CK16 recombinant protein is a key subject of research due to its potential applications in understanding skin biology and developing therapeutics for various dermatological conditions. CK16, or cytokeratin 16, is a type of intermediate filament protein predominantly expressed in the epidermis, particularly in areas subjected to mechanical stress, such as palms and soles. Elevated levels of CK16 are associated with hyperproliferative skin disorders, including psoriasis and eczema, making it a valuable biomarker for these conditions. Research on CK16 recombinant protein involves studying its role in cellular processes such as differentiation, proliferation, and response to injury, which are critical for maintaining skin integrity and function. Furthermore, the production of CK16 in recombinant form allows scientists to investigate its properties in vitro, facilitating the exploration of its interactions with other proteins and cellular components. By elucidating the molecular mechanisms governing CK16 function, researchers aim to develop targeted therapies that could modulate its activity in pathological conditions, ultimately leading to innovative treatments for skin diseases. Overall, the study of CK16 recombinant protein not only enhances our understanding of keratinocyte biology but also holds promise for advancing dermatological science and improving patient outcomes.
