Analytical Data
-
Gene name
MMP2
- Application
-
Alternative Names
CLG4; CLG4A; MMP-II; MONA; TBE-1; PEX; Gelatinase A; 72kDa Gelatinase; 72kDa Type IV Collagenase
-
Species
Rat
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
-
-
Expression Region
Tyr445~Cys662
-
Molecular Weight
27kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Matrix metalloproteinase 2 (MMP2) is a prominent member of the matrix metalloproteinase family, which plays a crucial role in extracellular matrix (ECM) remodeling, tissue remodeling, and various physiological and pathological processes, including embryogenesis, wound healing, and cancer metastasis. MMP2 specifically targets type IV and type V collagen, making it vital for the turnover of the basement membrane and tissue integrity. Dysregulation of MMP2 activity has been implicated in numerous diseases, including cancer, cardiovascular disorders, and inflammatory conditions, highlighting its potential as a therapeutic target. Research on recombinant MMP2 has gained momentum due to its applications in drug development and as a biotechnological tool. By producing recombinant MMP2, researchers can investigate its structure-function relationships, mechanism of action, and interactions with inhibitors and substrates. Additionally, recombinant MMP2 can be used to study the enzyme's role in disease progression and to develop innovative therapeutic strategies aimed at modulating its activity. Understanding MMP2's role in health and disease offers the potential for targeted interventions, making it a critical focus in biomedical research. Hence, studying MMP2 as a recombinant protein not only enhances our basic understanding of ECM dynamics but also opens avenues for innovative treatments for diseases associated with MMP imbalances.
