Analytical Data
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Gene name
MMP13
- Application
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Alternative Names
CLG3; Collagenase 3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P45452
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Expression Region
Leu290~Ile468
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Matrix metalloproteinase 13 (MMP13), also known as collagenase-3, is a member of the matrix metalloproteinase family, and plays a crucial role in the degradation of extracellular matrix components, particularly collagen. This enzyme has garnered significant interest in biomedical research due to its involvement in various physiological and pathological processes, including tissue remodeling, wound healing, and the progression of diseases such as osteoarthritis and cancer. Elevated levels of MMP13 have been associated with the degradation of cartilage and the metastasis of tumor cells, making it a potential biomarker for these conditions. Thus, there is a growing need for understanding the structure and function of MMP13 to identify suitable therapeutic targets and develop effective treatments. Research on recombinant MMP13 protein aims to elucidate its mechanistic pathways and interactions, providing insights that could lead to novel interventions. Furthermore, recombinant MMP13 can be utilized in various assays to screen for inhibitors that may mitigate its activity in disease contexts. Overall, the study of MMP13, particularly in its recombinant form, is essential for advancing our knowledge of matrix biology and its implications in health and disease.
