Analytical Data
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Gene name
PAK3
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简介
PAK3 is a serine/threonine kinase that plays a key role in multiple signaling pathways, affecting cytoskeletal dynamics, cell migration, and cell cycle. Its involvement in dendritic spine morphogenesis and synapse formation emphasizes its importance in neuronal processes. PAK3 Protein, Human (sf9) is the recombinant human-derived PAK3, expressed by Sf9 insect cells, with tag Free labeled tag.
- Application
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75914-1
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Expression Region
M1-R559
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Protein Length
Full Length of Isoform-1
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PAK3, a member of the p21-activated kinase (PAK) family, is a serine/threonine kinase that plays a crucial role in various cellular processes, including cytoskeletal dynamics, cell motility, and survival signaling. This kinase is particularly important in the context of neurological development and function, as it is involved in synaptic plasticity and cognitive processes. Recent studies have highlighted the significance of PAK3 in neurodevelopmental disorders, particularly those associated with intellectual disabilities and autism spectrum disorders, where mutations in the PAK3 gene have been implicated. Research into PAK3 has gained momentum due to its potential as a therapeutic target, with efforts focused on understanding its structure, regulatory mechanisms, and interaction with other signaling pathways. The reconstitution of PAK3 as a recombinant protein allows for in-depth biochemical and biophysical studies, facilitating the investigation of its enzymatic activity, substrate specificity, and role in cellular signaling networks. Understanding PAK3's function at the molecular level may provide insights into its contribution to disease pathogenesis and open up new avenues for targeted therapies in neurodevelopmental and neuropsychiatric conditions.
