Analytical Data
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Gene name
PAK2
- Application
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Alternative Names
PAK65; PAKgamma; p58; S6/H4 Kinase; Serine/threonine-protein kinase PAK 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13177
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Expression Region
Glu177~Ala419
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Molecular Weight
32kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PAK2 (p21-activated kinase 2) is a crucial member of the p21-activated kinase family, which plays a significant role in various cellular processes, including cell motility, survival, and proliferation. It is a serine/threonine kinase that is activated by small GTPases, such as Cdc42 and Rac1, and is involved in signaling pathways that regulate cytoskeletal dynamics and gene expression. Research on PAK2 has gained momentum due to its implications in various diseases, including cancer and neurodegenerative disorders, where its dysregulation can contribute to tumor progression and metastasis. The study of recombinant PAK2 proteins has become essential for understanding its structure-function relationships, enzymatic activity, and interactions with other cellular components. By producing and analyzing these recombinant proteins, researchers aim to unravel the mechanisms through which PAK2 exerts its biological effects and to identify potential therapeutic targets for interventions in diseases associated with abnormal PAK2 activity. Current investigations focus on its role in promoting cancer cell migration and invasion, as well as its involvement in cytoskeletal reorganization. Furthermore, the development of specific PAK2 inhibitors is of great interest in pharmacological research, as they may offer novel strategies for cancer treatment. Overall, the exploration of PAK2 recombinant proteins not only enhances our understanding of this kinase's fundamental biology but also holds promise for advancing therapeutic options in various pathologies linked to its function.
