Analytical Data
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基因名
PARVA/alpha-Parvin
- Application
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别名
rHualpha-Parvin, His; PARVA; MXRA2; alpha-Parvin
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q9NVD7-1
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表达区间
M1-E372
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氨基酸序列
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVEHHHHHH
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蛋白长度
Full Length of Isoform-1
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分子量
50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PARVA, also known as alpha-Parvin, is a member of the Parvin family of proteins, which play crucial roles in cellular adhesion and signaling pathways. These proteins are primarily involved in the formation of focal adhesions, where cells adhere to the extracellular matrix, facilitating communication between the inside of the cell and the surrounding environment. Research on PARVA has gained momentum due to its implications in various biological processes, including cell migration, proliferation, and differentiation. Dysregulation of PARVA expression or function has been linked to several pathologies, notably cancer, where altered cell adhesion and migration can contribute to tumor progression and metastasis. Through recombinant protein studies, scientists aim to elucidate the molecular mechanisms by which PARVA interacts with other proteins and facilitates the assembly of signaling complexes at focal adhesions. Understanding these interactions at a structural and functional level can provide insights into the role of PARVA in health and disease. The study of PARVA not only enhances our understanding of fundamental cell biology but also holds potential for the development of therapeutic strategies targeting diseases linked to aberrant PARVA function. Thus, the exploration of PARVA/alpha-Parvin as a recombinant protein offers a promising avenue for advancing our knowledge of its biological significance and therapeutic potential.
