Analytical Data
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Gene name
PRKCZ
- Application
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Alternative Names
PKC2; PKC-Z; PRKCZ; Protein Kinase M Zeta
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q05513
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Expression Region
Pro404~Ser591
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Molecular Weight
27kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PRKCZ, or Protein Kinase C Zeta, is a member of the protein kinase C (PKC) family, which plays a crucial role in cellular signaling, including regulation of cell growth, differentiation, and apoptosis. The importance of PRKCZ in various biological processes has generated significant interest in its function and regulation, especially in the context of cancer and neurodegenerative diseases. Abnormal expression or activity of PRKCZ has been implicated in several pathologies, marking it as a potential therapeutic target. Researchers have focused on the production of recombinant PRKCZ protein to better understand its structure, function, and interactions at the molecular level. The use of recombinant protein allows for detailed biochemical assays, structural studies, and the exploration of potential inhibitors. Techniques such as site-directed mutagenesis and molecular modeling have been employed to elucidate the mechanisms of PRKCZ action and its role in signal transduction pathways. Understanding PRKCZ's functions and regulatory mechanisms is essential not only for uncovering its role in disease but also for potential therapeutic interventions designed to modulate its activity. As our knowledge of PRKCZ expands, it holds promise for advancing our understanding of related signaling networks and developing novel strategies for disease treatment.
