Analytical Data
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基因名
Calreticulin/CALR
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简介
The calreticulin/CALR protein acts as a calcium-binding partner and promotes endoplasmic reticulum folding, assembly, and quality control. It interacts with monoglucosylated glycoproteins and mediates nuclear export of the NR3C1 DNA-binding domain. Calreticulin/CALR Protein, Mouse (P.pastoris, His, solution) is the recombinant mouse-derived Calreticulin/CALR protein, expressed by P. pastoris , with N-6*His labeled tag.
- Application
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别名
Calr; Calreticulin; CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP
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种属
Mouse
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表达系统
P. pastoris
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14211
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表达区间
D18-L416
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氨基酸序列
DPAIYFKEQFLDGDAWTNRWVESKHKSDFGKFVLSSGKFYGDLEKDKGLQTSQDARFYALSAKFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPSGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDDDRDEDEDEEDEKEEDEEESPGQAKDEL
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蛋白长度
Full Length of Mature Protein
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分子量
48.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of ERG (E26 transformation-specific related gene) recombinant proteins has garnered significant attention due to their critical role in various biological processes and disease mechanisms, particularly in cancer. ERG is a member of the ETS transcription factor family, which is involved in regulating gene expression during development and differentiation. Its overexpression has been implicated in several malignancies, most notably prostate cancer, where it is often fused with the androgen-regulated TMPRSS2 gene, creating a novel oncoprotein that promotes tumor growth and progression. Researchers have focused on developing recombinant ERG proteins to better understand their structure-function relationships, post-translational modifications, and interaction with other cellular proteins. By producing these proteins using recombinant DNA technology, scientists can investigate their biochemical properties, signaling pathways, and roles within the tumor microenvironment. Moreover, these studies aim to identify potential therapeutic targets and develop strategies for intervention that could lead to more effective treatments for cancers driven by ERG. The ongoing research surrounding ERG recombinant proteins not only sheds light on the molecular underpinnings of oncogenesis but also holds promise for innovative approaches in cancer diagnosis and therapy.
